国晋菘，博士，副研究员，中国科学技术大学硕士生导师。2018年毕业于北京大学，具有口腔临床医学硕士和生物医学工程博士双学位。2018年9月加盟中科院苏州医工所，历任助理研究员、副研究员。2022年获聘中科院特聘骨干研究岗位，先后主持和承担了国家重点研发计划、国家自然基金、江苏省双创计划、苏州市科技计划等多项人才和科研项目。申请国内外发明专利10余项（含国际PCT专利1项），已授权发明专利5项。在SCI 收录期刊上发表论文30余篇。详情请参考ResearchGate (RG): https://www.researchgate.net/profile/Jinsong-Guo-3?declinedAuthorUid=2093822443

2019年，江苏省双创博士；

2021年，省级医学科技一等奖；

2022年，省级科技进步二等奖；

2022年，苏州青年精英创业大赛三等奖；

高压放电与等离子体技术在生物医学领域的应用基础研究

多物理场对肿瘤免疫微环境和肿瘤侵袭转移的调控作用研究

1.       国家重点研发计划课题项目，2020YFC0122301，2020-10至2023-09，经费154万，负责人；

2.       江苏省双创博士人才项目，Y1188006038，2019-10至2022-09，经费15万，负责人；

3.       国家重点研发计划子课题项目，2020YFC0122304，2020-10至2023-09，经费23万，负责人；

4.       苏州市基础研究试点项目，SJC2022008，2022-07 至2024-6，经费50万，负责人；

5.       国家自然科学基金委项目，81772334, 2018-01至2021-12，经费55万，技术骨干；

6.       国家重点研发计划课题项目，2019YFC0119100，2019-12至2022-09，经费148万，技术骨干；

7.       境内委托横向项目，E149370201，2021-11至2024-02，经费200万，技术骨干；

[1] Guo, J#., Chen, C., Sun, Z., Zhang, L., Li, H., Wu, X., & Zhuang, J. (2023). Intense nano-pulse stimulation-induced dynamic changes in vesicle trafficking visualized by super-resolution fluorescence microscopy. Applied Physics Letters, 123(7).

[2] Zhuang, J., Yuan, Q., Chen, C., Liu, G., Zhu, K., Zhong, Z., & Guo J*. (2023). Nanosecond pulsed cold atmospheric plasma jet suppresses proliferation and migration of human glioblastoma cells via apoptosis promotion and EMT inhibition. Archives of Biochemistry and Biophysics, D-23-00501R.

[3] Zhuang, J., Shi, F., & Guo, J. (2023). Biomedical Applications of Pulsed Discharge and Pulsed Electric Field. In Pulsed Discharge Plasmas: Characteristics and Applications (pp.737-760). Singapore: Springer Nature Singapore.

[4] Liu, G., Shi, F., Wang, Q., Zhang, Z., Guo J*., & Zhuang, J. (2022). Penetration effect of the kINPen plasma jet investigated with a 3D agar-entrapped bacteria model. Microchemical Journal, 183, 107973.

[5] Sun K., Lu X., Yin C., Guo J*. (2022). In vitro antitumor activity of nano-pulse stimulation on human anaplastic thyroid cancer cells through nitric oxide-dependent mechanisms. Bioelectrochemistry, 108093.

[6] Zhu, C., Chen, C., Guo, J., Wang, Q., Rao, J., Li, H., ... & Zhuang, J. Cold atmospheric plasma inhibits vesicle transport of human osteosarcoma cells visualized by super‐resolution fluorescence microscopy. Plasma Processes and Polymers, e2100210.

[7] Gu, Y., Zhang, L., Yang, H., Zhuang, J., Sun, Z., Guo, J*., & Guan, M. (2021). Nanosecond pulsed electric fields impair viability and mucin expression in mucinous colorectal carcinoma cell. Bioelectrochemistry, 141, 107844.

[8] Zhang, L., Shi, F., Guo, J., Wang, Q., Kolb, J. F., Wang, W., ... & Zhuang, J. (2021). Impedimetric characterization of normal and cancer cell responses after nano-pulse stimulation. Journal of Physics D: Applied Physics, 54(18), 185401.

[9] 廖非, 杨晨, 曹莉, 钱春燕, 庄杰, 国晋菘. (2021). 大气压低温等离子体对大鼠急性化脓性感染伤口愈合的影响. 中国皮肤性病学杂志, 35(8), 6.

[10] Ning, T., Guo, J., Zhang, K., Li, K., Zhang, J., Yang, Z., & Ge, Z. (2019). Nanosecond pulsed electric fields enhanced chondrogenic potential of mesenchymal stem cells via JNK/CREB-STAT3 signaling pathway. Stem cell research & therapy, 10(1), 1-12.

[11] Liu, J., Lu, Q., Liang, R., Guo, J., Wang, K., Dong, F., ... & Fang, J. (2019). Communicating with mouse oocytes via regulating calcium oscillation patterns by nanosecond pulsed electric fields. Physical Review Applied, 11(2), 024001.

[12] Hongzhuan, Z., Ying, T., Xia, S., Jinsong, G., Zhenhua, Z., Beiyu, J., ... & Jing, F. (2020). Preparation of the inactivated Newcastle disease vaccine by plasma activated water and evaluation of its protection efficacy. Applied microbiology and biotechnology, 104(1), 107-117.

[13] Guo, J#., Dong, F., Ding, L., Wang, K., Zhang, J., & Fang, J. (2018). A novel drug-free strategy of nano-pulse stimulation sequence (NPSS) in oral cancer therapy: In vitro and in vivo study. Bioelectrochemistry, 123, 26-33.

[14] Guo, J#., Dang, J., Wang, K., Zhang, J., & Fang, J. (2018). Effects of nanosecond pulsed electric fields (nsPEFs) on the human fungal pathogen Candida albicans: an in vitro study. Journal of Physics D: Applied Physics, 51(18), 185402.

[15] Dong, F., Zhang, J., Wang, K., Liu, Z., Guo, J., & Zhang, J. (2019). Cold plasma gas loaded microbubbles as a novel ultrasound contrast agent. Nanoscale, 11(3), 1123-1130.

[16] Zhang, Y., Dong, F., Liu, Z., Guo, J., Zhang, J., & Fang, J. (2018). Nanosecond pulsed electric fields promoting the proliferation of porcine iliac endothelial cells: An in vitro study. PloS one, 13(5), e0196688.

[17] Tian, Y#., Guo, J.#, Wu, D., Wang, K., Zhang, J., & Fang, J. (2017). The potential regulatory effect of nitric oxide in plasma activated water on cell growth of Saccharomyces cerevisiae. Journal of Applied Physics, 122(12), 123302.

[18] Yang, Y., Guo, J., Zhou, X., Liu, Z., Wang, C., Wang, K., ... & Wang, Z. (2018). A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An in vitro study. Dental Materials Journal, 37(1), 157-166.

[19] Guo, J.#, Wang, Y., Wang, J., Zhang, J., & Fang, J. (2017). Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields (nsPEFs). Bioelectrochemistry, 113, 35-41.

[20] Guo, J.#, Ma, R., Su, B., Li, Y., Zhang, J., & Fang, J. (2016). Raising the avermectins production in Streptomyces avermitilis by utilizing nanosecond pulsed electric fields (nsPEFs). Scientific Reports, 6(1), 1-10.

主要发明专利：

[1] 国晋菘， 庄杰， 石富坤，刘更亮。 一种微生物-琼脂三维模型及其制备方法和应用。专利号：202211287163（公开）

[2] 国晋菘，张珏，方竞。一种提高阿维菌素产量的方法，专利号：201510441003.3（授权）

[3] 张宇晨，董飞宏，国晋菘，张珏，方竞。一种血管支架的快速内皮化设备及其方法，专利号：201710655499.3（授权）

[4] 鹿群，刘佳卉，梁蓉，国晋菘，王建六，王凯乐，董飞宏，张珏，方竞。一种卵母细胞激活的物理方法及其受精潜能的评价指标，专利号：201710692030.7（授权）

[5] Zigang, G. E., Tong, N. I. N. G., Zhang, J., Chen, J., Guo, J., & Li, K. (2021). U.S. Patent Application No. 17/264,864.