从事临床体外诊断研发和产业化二十多年。2014年回国任中国科学院“百人计划”特聘研究员，博士生导师，依托中国科学院苏州生物医学工程技术研究所建立核酸检测技术研究中心；承担或验收多项国家和地方重大研发项目。回国前在美国硅谷担任BioChain公司首席技术官；在美国拜耳诊断和西门子医疗（Bayer Diagnostics和Siemens Healthcare Diagnostics）担任主任科学家十二年。国家高端外国专家；姑苏创新创业领军人才；江苏省双创领军人才；国家药监局器审中心评审专家；江苏省人才创新创业促进会会员；江苏省免疫学会转化医学专业委员会“产学研学组”常务委员；北美华人生物医药协会（CABS）主任委员，终身会员；美国国家癌症中心（NCI），NIH肿瘤早期诊断研究协会（EDRN）会员、PI等。
1、 国家高端外国专家（2021）
2、 江苏省双创领军人才（2015）
3、 苏州市紧缺高层次人才（2015）
4、 苏州市姑苏创新创业领军人才（2014）
5、 苏州市高新区科技创新创业领军人才（2014）
6、 中国科学院苏州生物医学工程技术研究所首届“先进生物医学工程项目商业计划书比赛”特等奖（2014）
7、 中国科学院“百人计划”（2014）
8、 美国硅谷BioChain公司，成功完成甲基化大肠癌筛查DNA提取和质控试剂盒量产，获得CFDA医疗器械产品注册证；成功完成NGS测序技术标记实体肿瘤FFPE样品基因组项目，形成CancerSeq系列产品（2013）
9、 美国硅谷BioChain公司，成功完成无创大肠癌早期筛查分子诊断技术在中国独家技术转让和量产；完成FFPE样品提取核酸的项目，并成功转入生产（2013）
10、 美国西门子公司，服务十年荣誉奖（2011）
11、 美国西门子诊断，启动实施科研项目高通量DNA二代测序（NGS）和云计算方法用于 艾滋病个性化治疗，并同美国Illumina公司结盟，为NGS平台MySeq进入临床诊断奠定了基础（2010）
12、 西门子公司全球高管培训学校荣誉奖（2009）
13、 美国拜耳诊断/西门子诊断，构建并领导宫颈癌筛查研发团队，成功开创了世界领先的生物信息系统热力学方法来解决多重核酸杂交的摸拟计算，大大降低体外诊断产品研发周期和成本（2008）
14、 美国拜耳公司，科学技术荣誉奖（2006）
15、 美国拜耳公司，团队荣誉奖（2005）
16、 美国加州大学伯克利分校，采用高分辨NMR和同位素标定方法解决了世界上最大的 RNA酶三维分子结构（发表于2001年PNAS杂志）（2000）
17、 美国加州大学伯克利分校PMMB Fellow (Program in Mathematics and Molecular Biology)（1998）
18、 美国Bayer Foundation Scholarship, Univ. Houston（1998）
19、 美国Welch Foundation Fellowship, Univ. Houston（1995）
1、 分子诊断、体外诊断、精准医疗
2、 肿瘤早期筛查和诊断
3、 核酸热力学
1. Cao, Y., Zhao, G., Tian, Y., Chen, Z., Liu, X., Yuan, M., Yang, J., Wang, X., Ma, Y., Liu, Z., Xiong, S*., Zheng, M*., Fei, S*., Feasibility of methylated CLIP4 in stool for early detection of colorectal cancer: a training study in Chinese population, Frontiers in Oncology, 2021.（SCI）
2. Zhang, G., He, F., Zhao, G., Huang, Z., Li, X., Xia, X., Guo, Y., Xu, W., Xiong, S., Ma, Y., Zheng, M*., Liu, W*., Combining serum DNA methylation biomarkers and protein tumor markers improved clinical sensitivity for early detection of colorectal cancer, International Journal of Genomics, 2021.（SCI）
3. Liu, Z., Zhao, C., Zhao, G., Xiong, S*., Ma, Y*., Zheng, M*., Disruptors, a new class of oligonucleotide reagents, significantly improved PCR performance on templates containing stable intramolecular secondary structures, Analytical Biochemistry, 2021.（SCI）
4. Zhao, G., Liu, X., Liu, Y., Ma, Y., Yang, J., Li, H., Xiong, S., Fei, Y*., Zheng, M*., Zhao, X*., Methylated SFRP2 and SDC2 in Stool Specimens for Colorectal Cancer Early Detection: A Cost-effective Strategy for Chinese Population, Journal of Cancer, 2021.（SCI）
5. Cao, Y., Zhao, G., Yuan, M., Liu, X., Ma, Y., Cao, Y., Miao, B., Zhao, S., Li, D., Xiong, S*., Zheng, M*., Fei, S*., KCNQ5 and C9orf50 methylation in stool DNA for early detection of colorectal cancer, Frontiers in Oncology, 2021.（SCI）
6. Zhao, G., Wang, Z., Xiong, S., Liu, X., Zhu, Y., Li, S., Ma, Y*., Zheng, M*., Feasibility of Multiplex Methylated DNA Testing in Serum for Detection of Upper Gastrointestinal Tract Cancers, Test Engineering and Management, 2020.（SCI）
7. Zhao, G., Liu, X., Liu, Y., Li, H., Ma, Y., Li,S., Zhu, Y., Miao, J.,Xiong, S*., Fei, S* Zheng, M*., Aberrant DNA Methylation of SEPT9 and SDC2 in Stool Specimens as an Integrated Biomarker for Clolorectal Cancer Early Detection, Front Genet, 2020.（SCI）
8. Zhao, G., Ma, Y., Li, H., Li, S., Zhu, Y., Liu, X., Xiong, S., Liu, Y., Miao, J., Fei, S*., Zheng, M*., Zhao, X*., A novel plasma based early colorectal cancer screening assay based on methylated SDC2 and SFRP2, Clinica Chimica Acta, 2020.（SCI）
9. Miao, J., Liu, Y., Zhao, G., Liu, X., Ma, Y., Li, H., Li,S., Zhu, Y., Xiong, S*., Zheng, M*., Fei, S*., Feasibility of plasma methylated SFRP2 for early detection of gastric cancer, Cancer Control, 2020.（SCI）
10. Zhao, G., Liu, Y., Miao, J., Li, H., Ma, Y., Liu, X., Li,S., Zhu, Y., Xiong, S*., Zheng, M*., Fei, S*., Performance comparison between plasma and stool methylated SEPT9 tests for detecting colorectal cancer, Frontiers in Genetics, 2020.（SCI）
11. Liu, Z., Sun, J., Zhao, G., Xiong, S., Ma, Y., Zheng, M*., Transient stem-loop structure of nucleic acid template may interfere with__polymerase chain reaction through endonuclease activity of Taq DNA__polymerase, Gene, 2020.（SCI）
12. Zhao, G., Li, H., Yang, Z., Wang, Z., Xu, M., Xiong, S., Li, S., Wu, X., Liu, X., Wang, Z., Zhu, Y., Ma, Y*., Fei, S*., Zheng, M*., Multiplex Methylated DNA Testing in Plasma with High Sensitivity and Specificity for Colorectal Cancer Screening, Cancer Medicine, 2020.（SCI）
13. Sun, J., Tian, Y., Du, Y., Wang, Z., Zhao, G*., Ma, Y*., Zheng, M*., A Cautionary Tale of Cross Contamination among Plasmids from Commercial Suppliers, Biotechniques, 2020.（SCI）
14. Sun, J., Shi, Y., DU, Y., Wang, Z., Liu, Z., Wang, H., Zhao,G*., Ma, Y*., Zheng, M*., Rapid detection of diarrheagenic Escherichia coli in food by a new multiplex real-time Quantitative PCR Assay, Applied Biochemistry and Microbiology, 2020.（SCI）
15. Du, Y., Zhao, G., Liu, Z., Sun, J., Zheng, M*., Ma, Y*., Comparison of CerviHPV and cobas 4800 HPV Tests for Detection of High-risk HPV Infection in Cervical Swab Specimens, Journal of Reproductive Medicine, 2020.（SCI）
16. Li, H., Wang, Z., Zhao, G., Ma, Y., Chen, Y., Xue, Q., Zheng, M*., Fei, S*., Performance of a MethyLight assay for methylated SFRP2 DNA detection in colorectal cancer tissue and serum, The International Journal of Biological Markers, 2019. SCI）
17. Chen, Y., Wang, Z., Zhao, G., Sun, C., Ma, Y., Zhang, L., Zheng, M*., Li, H*., Performance of a Novel Blood based Early Colorectal Cancer Screening Assay in Remaining Serum after Blood Biochemical Test, Clinical Chemistry and Laboratory Medicine, 2019.（SCI）
18. Zhao, G., Tian, Y., Du, Y., Sun, J., Wang, Z., Ma, Y*., Zheng, M*., Comparison of CerviHPV and Hybrid Capture 2 HPV Tests for Detection of High-risk HPV Infection in Cervical Swab Specimens, Diagnostic Cytopathology, 2018.（SCI）
19. Zhao, G., Liu, Z., Tian, Y., Zhu, M., Wang, S., Wang, H., Gao, S., Ma, Y*., Zheng, M*., Stability, Integrity and Recovery Rate of Cellular Nucleic Acids Preserved in a New Liquid-Based Cytology Medium, Diagnostic Cytopathology, 2018.（SCI）
20. Hu, R., Zheng, M., Wu, J., Li, C., Shen, D., Yang, D., Li, L., Ge, M., Chang, and Dong, W. Core-Shell Magnetic Gold Nanoparticles for Magnetic Field-Enhanced Radio-Photothermal Therapy in Cervical Cancer, Nanomaterials, 2017.（SCI）
21. Zheng, M., Han, X., Gao, X., Strand polarity of trinucleotide repeat sequences: NMR studies parallel/anti-parallel duplex, {d(GAC)3}2, Protein Data Bank, 2003.（SCI）
22. Zheng, M., Wu, M., Tinoco, I. Jr., Formation of a GNRA tetraloop in the extended P5abc subdomain of Tetrahymena group I ribozyme can disrupt an inter-domain interaction, Proc. Natl. Acad. Sci. USA 98, 2001.（SCI）
23. Kao, C., Rudisser, S., Zheng, M., A simple and efficient method to transcribe RNAs with reduced 3' heterogeneity, Methods, 2001.（SCI）
24. Kao, C., Rudisser, S., Zheng, M., A simple and efficient method to transcribe RNAs with homogenous 3’ Ends. Promega Notes, 2001.（SCI）
25. Zheng, M., Tinoco, I. Jr., High resolution NMR spectroscopy of ribozymes. In Ribozyme Biochemistry and Biotechnology. 297-314, Eds. Krupp. G. and Gaur, R. Eaton Publishing, Natick, [Invited book chapter], 2000.
26. Zheng, M., Wu, M., Silverman, S., Cech, T., Tinoco, I., Jr., RNA folding and mutation studies of the P5abc subdomain from the tetrahymena group I intron ribozyme, FASEB Journal, 1999.（SCI）
27. Silverman, S., Zheng, M., Wu, M., Tinoco, I. Jr., Cech, T. R., Quantifying the energy interplay of RNA tertiary and secondary structure interactions, RNA, 1999.（SCI）
28. Kao, C., Zheng, M., Rudisser, S., A simple and efficient method to reduce nontemplated nucleotide addition at the 3' terminus of RNAs transcribed by T7 RNA polymerase, RNA 5, 1999.（SCI）
29. Gao, X., Huang, X., Smith, G. K., Zheng, M., Structure and dynamics of single stranded nucleic acids containing trinucleotide repeats. In Genetic instabilities and hereditary neurological diseases, 623-644. Eds. Warren, S. T. and Wells, R. D., Academic Press, San Diego, [Invited review], 1998.
30. Gao, X., Huang, X., Zheng, M., Smith, G. K., Ji, J., Structure, flexibility and folding of single stranded DNA triplet repeats. Biophysical Journal, 1998.（SCI）
31. Zheng, M., Study of the structure and stability of DNA trinucleotide repeat sequences by nuclear magnetic resonance spectroscopy, Ph.D.Thesis, Department of Chemistry, University of Houston, 1997.
32. Zheng, M., Huang, X., Smith, K., Yang, X., Gao, X., Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding, An NMR and UV spectroscopic study, J. Mol. Biol, 1996.（SCI）
33. Gao, X., Huang, X., Smith, G. K., Zheng, M., Liu. H, A new antiparallel duplex Motif of DNA CCG repeats that is stabilized by extrahelical bases symmetrically located in the minor groove, J. Am. Chem. Soc, 1995.（SCI）
34. Gao, X., Smith, K., Huang, X., Zheng, M, Unusual solution structures unveiled by NMR studies of single-stranded DNA triplet repeats, FASEB Journal, 1995.（SCI）
35. Wang, W., Liang, C., Zheng, M., Gao, X., Selective acylation of N-(2-Phosphonoethyl) ethylenediamine phosphonates, Tetrahedron Letters 36, 1995.（SCI）
知识产权：
1. 郑岷雪，马勇，赵国栋，刘派，李甲，宫颈细胞保存及DNA快速提取一体试剂盒和提取方法，发明专利，ZL201510896289.4
2. 郑岷雪，马勇，赵国栋，高信噪比多探针PCR Taqman探针及其应用，发明专利，ZL 201710184261.7
3. 郑岷雪，马勇，赵国栋，对多种高危型人乳头瘤病毒实现分型的试剂盒，发明专利，ZL201711367631.7
4. 刘兆成，马勇，郑岷雪，赵国栋，熊尚岷，用于提高具有二级结构的单链核酸分子的复制效率的试剂、核酸片段复制方法、应用，PCT国际专利，PCT/CN2021/131637
5. 顾兵，陈莹，赵呈雪，张林艳，马勇，郑岷雪，在单管qPCR中同时检测多种肠道致病菌的组合物、试剂盒及方法，发明专利，202111168379.3
6. 陈莹，顾兵，赵呈雪，张林艳，马勇，郑岷雪，使用多重qPCR快速检测并鉴定多种肠道致病菌的组合物、试剂盒及方法，发明专利，202111168378.9
7. 刘兆成，马勇，郑岷雪，赵国栋，熊尚岷，用于提高具有二级结构的单链核酸分子的复制效率的试剂、核酸片段复制方法、应用，发明专利，202011442674.9
8. 刘兆成，马勇，郑岷雪，赵国栋，熊尚岷，张春，用于提高腺相关病毒反向末端重复序列的复制效率的试剂 、腺相关 病毒DNA的复制方法、应用，发明专利，202011442675.3
9. 杜莹莹，古洁若，马勇，郑岷雪，痛风差异表达基因检测与急性发作预警试剂盒，发明专利，201810978764.6
10. 郑岷雪，马勇，赵国栋，对多种高危型人乳头瘤病毒实现分型的试剂盒，发明专利，ZL201711367631.7
11. Zheng, M., Quinn, J., Warner, B., Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation. 美国专利， US Patent No. US 8394944 B2
12. Zheng, M., Ku, L., Shen, L., Wong, C., Bush-Donovan, C., Reagents and methods for detecting CYP2C9 polymorphisms, 英国专利，EP2111465B1
13. Battersby, T., Fehr, A., Zheng, M., A method of normalizing biological samples, 国际专利， 2014015098 A1
14. Fehr, A., Battersby, T., Zheng, M., Dynamic Range Compression of Nucleic Acid Library Input for Next Generation Sequencing Systems. 美国专利，2012P10835US
15. Zheng, M., Ahle, D., Warner, B., Wu, M. and Chang, C., Highly orthogonal universal sequences for use in nucleic acid assays, 美国专利，US8063196B2
16. Zheng, M., Ahle, D., Warner, B., Wu, M., Chang, C, An orthogonal set of universal probe sequences for nucleic acid hybridization assays, 美国专利，US Patent application No. 11/049,465.
郑岷雪 研究员
研究方向：
电子邮件：minxue.zheng@sibet.ac.cn
电 话：0512-69588295
通讯地址：江苏省苏州市高新区科技城科灵路88号