周连群
国家高层次人才
国家重点研发计划首席科学家
博士，研究员，博士生导师, 国家高层次人才，国家重点研发计划项目首席科学家，中国科学院苏州生物医学工程技术研究所副所长。主持国家重点研发计划项目、国家自然科学基金、中国科学院先导科技专项、中国科学院重大科研仪器设备研制项目等国家/省部级项目10余项。任中国生物医学工程学会生物医学测量分会等委员。任《Biomedical Engineering Frontiers》、《光学精密工程》等期刊编委。主要从事生物医学检验创新技术和装备研究，在生物分子传感、单分子精准定量/单分子测序、超多重核酸检测等方面取得了一系列研究进展，相关成果获批三类医疗器械注册。先后入选国家重大人才计划、中国科学院青年促进会优秀会员、江苏省六大人才高峰高层次人才等。荣获科技部“全国科技系统抗击新冠肺炎疫情先进集体”、省科技进步一等奖等；发表SCI论文70余篇，申请发明专利70余项，授权发明专利40余项，国际PCT专利6项，获美国授权发明专利1项，专利转让/许可10余项。
微纳生物传感器及系统、生物医学检验技术、单分子测序、核酸传感芯片、空间组学检测、仪器精密机电技术、仪器结构优化设计
1. Hao Li, Jinze Li, Zhiqi Zhang, Qi Yang, Hong Du, Qiongzhu Dong, Zhen Guo, Jia Yao, Shuli Li, Dongshu Li, Nannan Pang, Chuanyu Li, Wei Zhang, Lianqun Zhou. Digital Quantitative Detection for Heterogeneous Protein and mRNA Expression Patterns in Circulating Tumor Cells, Advanced Science, 2024, 2410120.
2. Qingxue Gao, Jinze Li, Wei Zhang, Zhiqi Zhang, Runhu Huang, Peilin Zang, Shuli Li, Chao Li, Jia Yao, Chuanyu Li, Zhen Guo, Lianqun Zhou. a-SiC heteromorphic immersion nanocavities enabling wide-field real-time single-molecule detection, Biosensors and Bioelectronics, 2024, 116962.
3. Mingli Tao, Qi Yang, Changxiang Huan, Zhiqi Zhang, Peilong Li, Runhu Huang, Juan Li, Yueye Zhang, Chao Li, Chuanyu Li, Jia Yao, Shuli Li, Zhen Guo, Wei Zhang, Jinze Li, Lianqun Zhou. Multiplex methylation detection assays using a blocking FRET probe with machine learning-assisted quantitative melting curve method targeting early-stage breast cancer, Chemical Engineering Journal, 2024, 498:155093.
4. Chenhao Wang, Zhengyu Wang, Wei Wei, Zhenjie Zhang, Anne Ailina Li, Guanghao Huang, Xian Li, Shuzhi Sam Ge, Lianqun Zhou, Hui Kong. High-precision flexible sweat self-collection sensor for mental stress evaluation, npj Flexible Electronics, 2024,8: 47.
5. Zhenjie Zhang, Chenhao Wang, Jingzhang Wang, Wei Wei, Zhengyu Wang, Xian Li, Anne Ailina Li, Lianqun Zhou, Qing Wang, Hui Kong. Highly sensitive in-situ growth gold dendrite structure electrochemical sensor for early Alzheimer's disease screening, Chemical Engineering Journal, 2024, 490: 151644.
6. Lu Wang, Peilin Zang, Jinze Li, Zhiqi Zhang, Chao Li, Anran Zheng, Shasha Zhao, Jia Yao, Chuanyu Li, Zhen Guo, Wei Zhang, Lianqun Zhou. Single Effective Complex Loading into Zero-Mode Waveguides Optimized with Fluorescence Evaluation at Quenching and Accumulation Checkpoints. ACS Applied Materials & Interfaces, 2024, 16 (20), 25676.
7. Qi Xu, Jinze Li, Zhiqi Zhang, Qi Yang, Wei Zhang, Jia Yao, Yaxin Zhang, Yueye Zhang, Zhen Guo, Chao Li, Shuli Li, Changsong Zhang, Chuanxin Wang, Lutao Du, Chuanyu Li, Lianqun Zhou. Precise determination of reaction conditions for accurate quantification in digital PCR by real-time fluorescence monitoring within microwells. Biosensors and Bioelectronics, 2024, 244: 115798.
8. Anran Zheng, Zhen Guo, Chao Li, Zhiqi Zhang, Chuanyu Li, Jia Yao, Xin Wang, Jinze Li, Shasha Zhao, Weiguo Wang, Wei Zhang, Lianqun Zhou. A wide-range UAC sensor for the classification of hyperuricemia in spot samples. Talanta, 2024, 266(2): 125102.
9. Peilin Zang, Qi Xu, Chuanyu Li, Mingli Tao, Zhiqi Zhang, Jinze Li, Wei Zhang, Shuli Li, Chao Li, Qi Yang, Zhen Guo, Jia Yao, Lianqun Zhou. Self-correction of cycle threshold values by a normal distribution-based process to improve accuracy of quantification in real-time digital PCR. Analytical and Bioanalytical Chemistry, 2024, 416: 2453.
10. Yingxue Li, Qi Xu, Wei Zhang, Qi Yang, Zhen Guo, Chuanyu Li, Zhiqi Zhang, Qiongzhu Dong, Haoting Sun, Changsong Zhang, Chao Li, Jia Yao, Jinze Li, Lunxiu Qin, Lianqun Zhou. A highly-parallelized and low-sample-size chip for simultaneous detection of protein and nucleic acid biomarkers in hepatocellular carcinoma. Sensors and Actuators B: Chemical, 2023, 392: 134112.
11. Qingxue Gao, Peilin Zang, Jinze Li, Wei Zhang, Zhiqi Zhang, Chao Li, Jia Yao, Chuanyu Li, Qi Yang, Shuli Li, Zhen Guo, Lianqun Zhou. Revealing the binding events of single proteins on exosomes using nanocavity antennas beyond zero-mode waveguides. ACS Applied Materials & Interfaces. 2023, 15(42): 49511.
12. Anran Zheng, Chao Li, Shengkai Xu, Zhen Guo, Chuanyu Li, Changsong Zhang, Jia Yao, Zhiqi Zhang, Jinze Li, Lutao Du, Shasha Zhao, Chuanxin Wang, Wei Zhang, Lianqun Zhou. Efficient simultaneous detection of metabolites based on electroenzymatic assembly strategy. BME Frontiers, 2023, 4(10199): 0027.
13. Jia Yao, Yuanyuan Luo, Zhiqi Zhang, Jinze Li, Chuanyu Li, Chao Li, Zhen Guo, Lirong Wang, Wei Zhang, Heming Zhao, Lianqun Zhou. The development of real-time digital PCR technology using an improved data classification method. Biosensors and Bioelectronics, 2022, 199: 113873.
14. Hao Li, Jinze Li, Zhiqi Zhang, Zhen Guo, Changsong Zhang, Zixu Wang, Qiuquan Guo, Chao Li, Chuanyu Li, Jia Yao, Anran Zheng, Jingyi Xu, Qingxue Gao, Wei Zhang, Lianqun Zhou. Integrated microdevice with a windmill-like hole array for clog-free, efficient and self-mixing enrichment of circulating tumor cells, Microsystems & Nanoengineering, 2022, 8:23.
15. Anran Zheng, Wei Zhang, Chao Li, Zhen Guo, Chuanyu Li, Changsong Zhang, Jia Yao, Zhiqi Zhang, Jinze Li, Shasha Zhao, Lianqun Zhou. The heparinase-linked differential time method allows detection of heparin potency in whole blood with high sensitivity and dynamic range. Biosensors and Bioelectronics, 2022, 198: 113856.
16. Hui Kong, Wei Zhang, Jia Yao, Chao Li, Renfei Lu, Zhen Guo, Jinze Li, Chuanyu Li, Yingxue Li, Chiyu Zhang, Lianqun Zhou. A RT-LAMP based hydrogen ion selective electrode sensing for effective detection HIV-1 RNA with high-sensitivity. Sensors and Actuators B: Chemical, 2021, 329: 129118.
17. Guojun Cao, Jinze Li, Zhifang Xing, Zhiqi Zhang, Wei Zhang, Chuanyu Li, Longhui Li, Zhen Guo, Shuli Li, Xu Gao, Yanchun Ma, Lianqun Zhou, Ming Guan. Establishment of scalable nanoliter digital LAMP technology for the quantitative detection of multiple myeloproliferative neoplasm molecular markers. Sensors and Actuators B: Chemical, 2021, 346: 130493.
18. Hui Kong, Chuanyu Li, Zhen Guo, Wei Zhang, Jia Yao, Hongnan Zhu, Ruhong Yan, Lirong Wang, Jinze Li, Wei Wei, Lianqun Zhou. Sensitivity improved with Parylene-C passivized on Lamb wave sensor for aPTT measurement through monitoring whole blood reaction, Sensors and Actuators B-Chemical, 2019, 285: 479.
19. Wei Wei, Wei Zhang, Chuanyu Li, Hui Kong, Zhen Guo, Zhiqi Zhang, Francois Bastien, Yuehua Gong, Hongchao Wang, Lianqun Zhou. Label-free detection of pepsinogen 1 and 2 by polyethylene coating Lamb microfluidic device. Biosensors and Bioelectronics, 2019, 129: 231.
20. Chuanyu Li, Zhen Guo, Jia Yao, Hui Kong, Minghui Zan, Wenfei Dong, Lianqun Zhou, Yuguo Tang. Sensitivity-enhanced uncooled infrared detector based on a Lamb wave sensor with polydopamine coating. Applied Physics Letters, 2019, 114(18): 183505.
周连群 研究员
研究方向：
电子邮件：zhoulq@sibet.ac.cn
电 话：0512-69588005
通讯地址：苏州高新区科技城科灵路88号