博士，二级研究员，博士生导师，中国科学院特聘核心岗位，国家高层次人才，国家重点研发计划项目首席科学家，中国科学院苏州生物医学工程技术研究所副所长。主持国家重点研发计划项目、国家自然科学基金、中国科学院先导科技专项、中国科学院重大科研仪器设备研制项目等国家/省部级项目10余项。任中国生物医学工程学会生物医学测量分会等委员。任《Biomedical Engineering Frontiers》、《光学精密工程》等期刊编委。主要从事生物医学检验创新技术和装备研究，在生物分子传感、单分子精准定量/单分子测序、超多重核酸检测等方面取得了一系列研究进展，相关成果获批三类医疗器械注册。先后入选国家重大人才计划、中国科学院青年促进会优秀会员、江苏省六大人才高峰高层次人才等。荣获科技部“全国科技系统抗击新冠肺炎疫情先进集体”、省科技进步一等奖等；在J. Am. Chem. Soc.、Advanced Science、Microsyst. Nanoeng.、Biosens. Bioelectron.、Anal. Chem.等期刊发表SCI论文90余篇，申请发明专利70余项，授权发明专利40余项，国际PCT专利6项，获美国授权发明专利1项，专利转让/许可10余项。
国家高层次人才
国家重点研发计划首席科学家
微纳生物传感器及系统、生物医学检验技术、单分子测序、核酸传感芯片、空间组学检测、仪器精密机电技术、仪器结构优化设计
[1] Electrostatic-Driven Nucleobase Discrimination by Covalent Organic Framework Nanosheets for Deoxyribonucleic Acid Methylation Profiling. Journal of the American Chemical Society, 2026, 148(23): 23611-23627
[2] AI-assisted digital single-molecule activity tracker for decoupling intrinsic heterogeneity from photo-oxidative damage in high-photon-flux enzymology. Advanced Science, 2026, 0: e76238
[3] Spatial Transcriptomics and snRNA-seq Expose CAF Niches Orchestrating Dual Stromal-Immune Barriers in Hepatocellular Carcinoma. Advanced Science, 2025, 12(48): e14661.
[4] Deep Learning-Enabled Real-Time Single-Shot Refocusing of Microwell Array for Digital Melting Curve Analysis. Analytical Chemistry, 2025，97(45):25304-25316.
[5] Enhancing Classification Robustness in Real-Time Digital PCR via Amplification Curve Regulation and Clustering Analysis. Analytical Chemistry, 2025, 97(28): 15085-15092.
[6] Digital Quantitative Detection for Heterogeneous Protein and mRNA Expression Patterns in Circulating Tumor Cells. Advanced Science, 2025, 12(2): 2410120.
[7] a-SiC Heteromorphic Immersion Nanocavities Enabling Wide-field Real-time Single-Molecule Detection. Biosensors & Bioelectronics, 2025, 270: 116962.
[8] Precise Determination of Reaction Conditions for Accurate Quantification in Digital PCR by Real-time Fluorescence Monitoring within Microwells. Biosensors & Bioelectronics, 2024, 244: 115798.
[9] A Highly-parallelized and Low-sample-size Chip for Simultaneous Detection of Protein and Nucleic Acid Biomarkers in Hepatocellular Carcinoma. Sensors and Actuators B-Chemical, 2023, 392: 134112.
[10] Integrated microdevice with a windmill-like hole array for the clog-free, efficient, and self-mixing enrichment of circulating tumor cells. Microsystems & Nanoengineering, 2022, 8: 23.
周连群 研究员
研究方向：
电子邮件：zhoulq@sibet.ac.cn
电 话：0512-69588005
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