江伟男,中国科学院苏州医工所副研究员,主要研究方向为模拟多肽的高分子材料、生物材料、组织工程、生物医药、高端医疗器械、人工智能等领域交叉研究。以第一/共一作者在Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、J. Med. Chem.等期刊发表论文6篇,以共同作者在Nat. Biotechnol.、Nat. Microbiol.、Sci. Transl. Med.、Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Func. Mater.等期刊发表论文20余篇。
(团队常年招收博士、硕士研究生)
1. 模拟多肽的高分子材料,用于水凝胶、抗菌材料、医疗器械、骨软骨血管等组织修复、干细胞培养与治疗等。
2. 抗耐药细菌、真菌与抗肿瘤等多肽类药物发现,小分子药物和大分子生物药(蛋白/多肽、抗体、核酸等)修饰与递送。
3. 智能传感、脑机接口、生物芯片,人工智能与计算模拟驱动的生物材料与生物医药设计与发现。
1、国家自然科学基金青年基金项目,项目负责人,2027.1-2029.12,在研
2、国家自然科学基金联合基金重点支持项目,课题负责人,2026.1-2029.12,在研
3、国家资助博士后研究人员计划B档,项目负责人,2024.7-2026.6,结题
4、江苏省自然科学基金青年基金项目,项目负责人,2025.9-2028.6,在研
5、苏州市基础研究试点重点项目,项目负责人,2025.7-2028.6,在研
6、中国科学院特别研究助理项目,项目负责人,2024.7-2026.6,结题
7、中国博士后特别资助,项目负责人,2024.7-2026.6,结题
8、中国博士后面上资助,项目负责人,2024.7-2026.6,结题
近5年代表性论著(限5项):
1. Jiang, W.; Zhou, M.; Chen, K.; Xiao, X.; Shi, J.; Zhang, H.; Xie, J.; Chen, S.; Chen, M.; Cong, Z.; Liu, L.; Wu, Y.*; Liu, R.*, Biguanide-Functionalized Peptide Mimics Effectively Combat Drug-Resistant ESKAPE Pathogens and Meningitis. Nat. Commun. 2026, 17, 336.
2. Jiang, W.; Zhou, M.; Chen, S.; Xie, J.; Chen, M.; Zhang, H.; Wu, Y.; Chen, X.; Liu, R.*, Peptide-Mimicking Poly(2-oxazoline)s Possessing Potent Antifungal Activity and BBB Penetrating Property to Treat Invasive Infections and Meningitis. J. Am. Chem. Soc. 2023, 145 (47), 25753-25765. (入选“JACS Spotlight”,国基金委报导的基金资助重要成果)
3. Jiang, W. #; Zhou, M. #; Cong, Z.; Xie, J.; Zhang, W.; Chen, S.; Zou, J.; Ji, Z.; Shao, N.; Chen, X.; Li, M.; Liu, R.* Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections. Angew. Chem. Int. Ed. 2022, 134 (17), e202200778. (入选“Very Important Paper”)
4. Wu, Y. #; Jiang, W. #; Cong, Z.; Chen, K.; She, Y.; Zhong, C.; Zhang, W.; Chen, M.; Zhou, M.; Shao, N.; Xiao, G.; Shao, X.; Dai, Y.; Fei, J.; Song, G.; Liu, R.* An effective strategy to develop potent and selective antifungal agents from cell penetrating peptides in tackling drug-resistant invasive fungal infections. J. Med. Chem. 2022, 65 (10), 7296–7311.
5. Jiang, W. #; Wu, Y. #; Zhou, M. #; Song, G.; Liu, R.* Advance and Designing Strategies in Polymeric Antifungal Agents Inspired by Membrane-Active Peptides. Chem. - Eur. J. 2022, 28(65), e202202226. (入选“Very Important Paper”)
其它论著:
1. Liu, L.#; Zhou, M.#; Xiao, X.; Cong, Z.; Wu, Y.; Xie, J.; Zhang, Q.; Zhang, J.; Jiang, W.; Liu, R.*, Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles. Nat. Biotechnol. 2026, DOI: 10.1038/s41587-025-02930-3. (Nature Outlook官方报道的改写药物递送的六大进展)
2. Zhou, M.#; Liu, L.#; Cong, Z.; Jang, W.; Xiao X.; Xie J.; Luo, Z.; Chen, S.; Wu, Y.; Xue, X.; Shao, N.; Liu, R.* A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens, Nat. Microbiol. 2024, 9, 1325-1339. (国基金委报导的基金资助重要成果)
3. Xie, J.#, Zhou, M.#, Cong, Z., Xiao, X., Liu, L., Chen, S., Jiang, W., Wu, Y,. Liu, R.*, A host defense peptide-mimicking prodrug activated by drug-resistant Gram-negative bacterial infections. Sci. Transl. Med. 2025, 17, eadl4870. (Cover, Highlighted by Nat. Rev. Drug Discov., Highlighted by Cell Host & Microbe)
4. Zhang, H.; Liang, Q.; Jiang, W.; Chen, Q.; Chen, K.; Cong, Z.; Liu, G.; Shi, J.; Ji, Y.; Li, W.; Dou, M.; Wang, Y.; Liu, L.; Chen, L.; Zhang, D.; Wu, Y.; Liu, R.*., Poly(bis(guanidinium)-oxazoline)–Insulin Complex Exerting Long-Acting Glucose-Responsive Insulin Release in Mice and Minipigs. J. Am. Chem. Soc. 2025, 147 (44), 40576-40589.
5. Zhang, H.; Liang, Q.; Ji, Y.; Chen, Q.; Jiang, W.; Zhang, D.; Wu, Y.; Yu, L.*; Chen, W.*; Liu, R.*, Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing. Bioact. Mater. 2025, 53, 386-403.
6. Xie, J.; Liu, Z.; Zhou, M.*; Luo, Z.; Liu, L.; Xiao, X.; Jiang, W.; Hu, W.; Wu, Y.; Liu, R.* Self-assembled poly(sarcosine) functionalized host defense peptide-mimicking poly-β-peptides for combating drug-resistant fungal infection. Adv. Func. Mater. 2025, 35 (42), 2424125..
7. Zhang, D.#; Liu, J.#; Chen, Q.; Jiang, W.; Wang, Y.; Xie, J.; Ma, K.; Shi, C.; Zhang, H.; Chen, M.; Wan, J.; Ma, P.; Zou, J.; Zhang, W.; Zhou, F.; Liu, R.* A Sandcastle Worm-Inspired Strategy to Functionalize Wet Hydrogels. Nat. Commun. 2021, 12, 6331.
8. Xie, J. #; Zhou, M. #; Qian, Y.; Cong, Z.; Chen, S.; Zhang, W.; Jiang, W.; Dai, C.; Shao, N.; Ji, Z.; Zou, J.; Xiao, X.; Liu, L.; Chen, M.; Li, J.; Liu, R.* Addressing MRSA Infection and Antibacterial Resistance with Peptoid Polymers. Nat. Commun. 2021. 12, 5898.
9. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2-Oxazoline)-Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020. 59, 6412−6419.
10. Qiao, Z.#; Zhang, W.#; Wu, Y.#; Jiang, W.; Shao, N.; Xie, J.; Xia, G.; Chen, Q.; Liu, Z.; Zou, J.; Gu, J.; Luan, S.; Lin, H.; Liu, R.* Host Defense Peptide-Mimicking Peptide Polymer-Based Antibacterial Hydrogel Enables Efficient Healing of MRSA-Infected Wounds. Sci. China Chem. 2023. 66, 1824-1833.
江伟男 副研究员
研究方向:
电子邮件:jiangwn@sibet.ac.cn
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通讯地址:苏州市高新区科技城科灵路88号