张京钟，现任中国科学院苏州生物医学工程技术研究所研究员，博士生导师。2005年获首都医科大学神经生物学博士学位，2006年赴德国Helmholtz慕尼黑中心／德国环境健康研究中心、Max Delbruck分子医学研究中心从事神经发育、干细胞分化机制研究。2016年全职回国在中国科学院苏州医工所从事干细胞治疗重大疾病的机制研究和转化研究，现任中国神经科学学会神经干细胞和组织工程分会常务委员，中国生物工程学会干细胞与组织工程专委会常务委员，发表SCI论文50余篇，申请专利20余项。
在重大疾病的干细胞治疗和基因治疗研究中取得了较多成果，获得江苏省高层次创新创业人才、姑苏重大创新团队领军人才、苏州国家高新区科技创新创业领军人才、北京市科技新星、北京市科技进步二等奖、中华医学科技奖三等奖等荣誉称号和奖项。
1． 干细胞／类脑器官治疗神经系统重大疾病及其机制研究。
2． 类器官和微生理系统构建及应用。
1． 国家重点研发计划“干细胞研究与器官修复”专项（首席）。
2． 国家自然基金面上项目（项目负责人）。
3． 姑苏重大创新团队项目（领军人才）。
4． 中国科学院战略先导计划（项目骨干）。
5． 江苏省基础研究重点项目（项目骨干）。
近5年代表性论著（通讯作者）：
1. Non-monotonic response of macrophages to mechanical stretch impacts skin wound healing. Cell Mol Biol Lett. 2025 Jul 15;30(1):82. doi: 10.1186/s11658-025-00764-0. PMID: 40665211.
2. Single-cell Raman spectroscopy as a novel platform for unveiling the heterogeneity of mesenchymal stem cells. Talanta. 2025 Mar 12;292:127933. doi: 10.1016/j.talanta. 2025.127933. PMID: 40081243.
3. Activation of angiopoietin-1 signaling with engineering mesenchymal stem cells promoted efficient angiogenesis in diabetic wound healing. Stem Cell Res Ther. 2025 Feb 21;16(1):75. doi: 10.1186/s13287-025-04207-7. PMID: 39985096.
4. Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Impairments in a Diabetic Mouse Model via Inhibition of MMP-9 Activity. Int J Mol Sci. 2025 Apr 3;26(7):3355. doi: 10.3390/ijms26073355. PMID: 40244194.
5. Controlled release of mesenchymal stem cell-derived nanovesicles through glucose- and reactive oxygen species-responsive hydrogels accelerates diabetic wound healing. Journal of Controlled Release, 2024 Dec;376:985-998.
6. Neural Progenitor Cell-Mediated Magnetic Nanoparticles for Magnetic Resonance Imaging and Photothermal Therapy of Glioma. ACS Appl Bio Mater. 2024 Jul 15;7(7):4553-4561. doi: 10.1021/acsabm.4c00414.
7. Adipose-Derived Stem-Cell-Membrane-Coated PLGA-PEI Nanoparticles Promote Wound Healing via Efficient Delivery of miR-21. Pharmaceutics. 2024 Aug 23;16(9):1113.
8. High-Voltage Electrostatic Field Hydrogel Microsphere 3D Culture System Improves Viability and Liver-like Properties of HepG2 Cells. Int J Mol Sci. 2024 Jan 16;25(2):1081. doi: 10.3390/ijms25021081.
9. The composite biomatrix SC/CM improved the therapeutic effects of xenogeneic MSC on wound healing in immune-competent mice via immune niche reprogramming. J. Mater Sci., 2024,59, 15514–15528.
10. Cerebral-Organoid-Derived Exosomes Alleviate Oxidative Stress and Promote LMX1A-Dependent Dopaminergic Differentiation. Int J Mol Sci. 2023 Jul 4;24(13):11048. doi: 10.3390/ijms241311048.
11. Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation. Metabolism. 2023 Mar;140:155398. doi: 10.1016/j.metabol.2023.155398.
12. Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing. Bio-design and manufacturing, 2023；6：268–283.
13. In Situ-Formed Fibrin Hydrogel Scaffold Loaded With Human Umbilical Cord Mesenchymal Stem Cells Promotes Skin Wound Healing. Cell Transplant. 2023 32: 9636897231156215.
14. Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain. Molecular Biology, 2022;56(3):500-502.
15. Novel pneumatically assisted atomization device for living cell delivery and application of sprayed mesenchymal stem cells in skin regeneration. Bio- design and manufacturing, 2022; 5, 220–232.
16. The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells. Int J Mol Sci. 2021; 22(22): 12141
17. Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. 2021; 30(15):782-796.
18. Synthesis of SPIO nanoparticles and the subsequent applications in stem cell labeling for Parkinson's disease. Nanoscale Res Lett, 2021, 16:107.
19. Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor. Cell Proliferation, 2020 Aug;53(8):e12858.
20. Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction BDNF expression in developmental stages. Biochemical and Biophysical Research Communications, 2020, Vol.527(1): 311-316.
21. Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c‐MYC axis in breast cancer. J Cell Mol Med.，2020;24:2135–2144.
张京钟 研究员
研究方向：
电子邮件：zhangjz@sibet.ac.cn
电 话：
通讯地址：苏州市高新区科技城科灵路88号