研究员，细胞工程研究中心负责人，中国科学技术大学博士生导师，国家重点研发计划首席科学家。2005年获得神经生物学博士学位，在Helmholtz慕尼黑中心、德国环境健康研究中心从事神经发育、干细胞分化机制和干细胞转分化研究十余年。在重大疾病的干细胞治疗和基因治疗研究中取得了较多成果，获得江苏省高层次创新创业人才、姑苏重大创新团队领军人才、北京市科技新星、北京市科技进步二等奖等荣誉称号和奖项。发表论文40余篇，申请专利10余项，授权发明专利5项。
1. 中国神经科学学会神经干细胞和组织工程分会，委员。
2. 中国生物医学工程第九届青年工作委员会，委员。
3. 中国医学装备协会输血医学装备技术专委会，委员。
4. 国家重点研发计划、国家重大科技专项评审专家。
5. 中国生物工程学会干细胞与组织工程专委会常务委员。
干细胞治疗新技术研发；组织工程和再生医学；类器官芯片和微生理系统
1. 国家重点研发计划“干细胞研究与器官修复”专项：神经-循环-生殖微生理互作系统构建及其智能化评价体系（首席科学家）。
2. 国家自然基金面上项目：基于脐带间充质干细胞制备多巴胺能神经元的单细胞指纹图谱分析及其治疗帕金森病的实验研究（项目负责人）。
3. 姑苏重大创新团队项目：干细胞关键技术研发及其核心装备产业化开发（领军人才）
1. Ji X, Zhou S, Wang N, Wang J, Wu Y, Duan Y, Ni P, Zhang J, Yu S. Cerebral-Organoid-Derived Exosomes Alleviate Oxidative Stress and Promote LMX1A-Dependent Dopaminergic Differentiation. Int J Mol Sci. 2023 Jul 4;24(13):11048. doi: 10.3390/ijms241311048. (Corresponding author )
2. Fangzhou Du, Mengmeng Liu, Jingwen Wang , Lvzhong Hu , Dongao Zeng，Shaocong Zhou, Lixing Zhang , Meijia Wang , Xi Xu , Chenglong Li, Jingzhong Zhang, Shuang Yu. Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation. Metabolism--CLINICAL AND EXPERIMENTAL, 2023 Mar; 140:155398. (Corresponding author )
3. Mao J, Li J, Chen J, Wen Q, Cao M, Zhang F, Li B, Zhang Q, Wang Z, Zhang J, Shen J. CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma. J Immunother Cancer. 2023 Dec 6;11(12):e007481.
4. Wang L, Liu S, Li K, Ma A, Hu C, Wang C, Cao N, Zhao Y, Fu R, Jia W, Xiang P, Liu H, Qi Z, Zhu N, Liang L, Wang L, Cao J, Zhai P, Zhou J, Wei J, Na T, Wu J, He Z, Zhou G, Yu W, Wu J, Zeng W, Zhang Y, Zhu L, Fu B, Zhang J, Yang S, Dai C, Cui H, Jing J, Yan H, He X, Lu Y, Tong C, Zhao T, Hao J, Liu X, Jin Y, Wang Y. General requirements for the production of extracellular vesicles derived from human stem cells. Cell Prolif. 2023 Sep 28:e13554.
5. Menon R, Petrucci L, Lohrer B, Zhang J, Schulze M, Schichor C, Winner B, Winkler J, Riemenschneider MJ, K hn R, Falk S, Karow M.Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons. Cell Reprogram. 2023 Jun 27. doi: 10.1089/cell.2023.0008.
6. Lvzhong Hu, Jinhua Zhou, Zhisong He, Lin Zhang, Fangzhou Du, Mengting Nie, Yao Zhou, Hang Hao, Lixing Zhang, Shuang Yu, Jinzhong Zhang, Youguo Chen. In situ-formed fibrin hydrogel scaffold loaded with human umbilical cord mesenchymal stem cells promotes skin wound healing. Cell Transplantation. 2023; 32:9636897231156215. (Co-corresponding author )
7. Lixing Zhang, Xin Miao, Meijia Wang, Aihua Shi, Jingwen Wang, Zhonglin Ma, Yunhai Zhang, Jingzhong Zhang, Shuang Yu. Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing. Bio design and manufacturing, 2023；6：268–283. ( Corresponding author )
8. Y. C. Zhang, J. W. Wang, Y. Wu, Q. Tao, F. F. Wang, N. Wang, X. R. Ji, Y. G. Li, S. Yu*, J. Z. Zhang*. Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain. Molecular Biology, 2022;56(3):500-502. (Corresponding author )
9. Nana Wang, Xingrui Ji, Yue Wu, Shaocong Zhou, Huiyu Peng, Jingwen Wang, Shuang Yu*,and Jingzhong Zhang*. The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells. Int J Mol Sci. 2021; 22(22): 12141(Corresponding author )
10. Zhang L, Yan X, An L, Wang M, Xu X, Ma Z, Nie M, Du F, Zhang J*, Yu S. Novel pneumatically assisted atomization device for living cell delivery and application of sprayed mesenchymal stem cells in skin regeneration. Bio design and manufacturing, 2022; 5, 220–232. (Corresponding author )
11. Wang S, Shen H, Mao Q, Tao Q, Yuan G, Zeng L, Chen Z, Zhang Y, Cheng L, Zhang J, Dai H, Hu C, Pan Y, Li Y. Macrophage-Mediated Porous Magnetic Nanoparticles for Multimodal Imaging and Postoperative Photothermal Therapy of Gliomas. ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56825-56837
12. Yao Zhou, Jinhua Zhou, Xi Xu, Fangzhou Du, Mengting Nie, Lvzhong Hu, Yuhao Ma, Mengmeng Liu, Shuang Yu, Jingzhong Zhang*, Youguo Chen. Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. 2021; 30(15):782-796. (Co-corresponding author )
13. An L, Tao Q, Wu Y, Wang N, Liu Y, Wang F, Zhang L, Shi A, Zhou X, Yu S, Zhang J*. Synthesis of SPIO nanoparticles and the subsequent applications in stem cell labeling for Parkinson's disease. Nanoscale Res Lett, 2021, 16:107. (Corresponding author )
14. Jana Heppt, Marie-Theres Wittmann, Jingzhong Zhang, Daniela Vogt-Weisenhorn, Nilima Prakash, Wolfgang Wurst, Makoto Mark Taketo, D. Chichung Lie. -catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. EMBO Journal, 2020 Nov 2; 39(21): e104472.
15. Yan Liu, Yehui Zhou, Kuo-Hsiang Huang, Xujie Fang, Ying Li, Feifei Wang, Li An, Qingfei Chen, Yunchao Zhang, Aihua Shi, Shuang Yu, and Jingzhong Zhang*. Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor. CELL PROLIFERATION, 2020;00:e12858 (Corresponding author )
16. Qingfei Chen, Feifei Wang, Yunchao Zhang, Yan Liu, Li An, Zhongliang Ma, Jingzhong Zhang*, Shuang Yu. Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction BDNF expression in developmental stages. Biochemical and Biophysical Research Communications, 2020, Vol.527(1): 311-316 (Corresponding author )
17. Yang Z, Zheng C, Zhang F, Lin B, Cao M, Tian X, Zhang J, Zhang X, Shen J. Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis. Muscle Nerve. 2020 Mar 14. doi: 10.1002/mus.26862.
18. Mao J, Cao M, Zhang F, Zhang J, Duan X, Lu L, Yang Z, Zhang X, Zhu W, Zhang Q, Wang Z, Shen J. Peritumoral administration of IFN upregulated mesenchymal stem cells inhibits tumor growth in an orthotopic, immunocompetent rat glioma model. J Immunother Cancer. 2020 Mar;8(1). pii: e000164. doi: 10.1136/jitc-2019-000164.
19. Liu Y, Song H, Yu S, Huang K-H, Ma X, Zhou Y, Zhang J*, Chen L. Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c‐MYC axis in breast cancer. J Cell Mol Med.，2020;24:2135–2144. (Co-corresponding author )
20. Liu Y, Zhou Y, Huang KH, Li Y, Fang X, An L, Wang F, Chen Q, Zhang Y, Shi A, Yu S, Zhang J*. EGFR-specific CAR-T cells trigger cell lysis in EGFR-positive TNBC. Aging (Albany NY). 2019 Dec 4;11(23):11054-11072. (Corresponding author )
21. Yu N, Zhang X, Gao Y, You H, Zhang J*, Miao P. Highly Sensitive Endotoxin Assay Combining Peptide/Graphene Oxide and DNA-Modified Gold Nanoparticles. ACS Omega. 2019, 22; 4(10): 14312-14316. (Co-corresponding author )
22. Liu Y, Li J, Ma Z, Zhang J, Wang Y, Yu Z, Lin X, Xu Z, Su Q, An L, Zhou Y, Ma X, Yang Y, Wang F, Chen Q, Zhang Y, Wang J, Zheng H, Shi A, Yu S, Zhang J, Zhao W, Chen L. Oncogenic functions of Protein Kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. Cancer Med. 2019;8(2):729-741.
23. Zhenzhen Guo, Jun Xu, Jingzhong Zhang, Yayun Hu, Yue Pan, Peng Miao. Facile Strategy for Electrochemical Analysis of Hydrogen Peroxide Based on Multifunctional Fe3O4@Ag Nanocomposites. ACS Appl. Bio Mater. 2018, 1, 367？373.
24. Yu S，Zutschi I, Stoffel R, Zhang JZ, Silva PV, Sousa N, Costa PS, Holsboer F, Patchev A, Almeida OF.. Antidepressant responsiveness in adulthood is permanently impaired after neonatal destruction of the neurogenic pool. Trans Psychiatry. 2017, 7（1）：1~9.
25. Garrett L*, Zhang, J. *, Annemarie Zimprich, Kristina M. Niedermeier, Helmut Fuchs, Valerie Gailus-Durner, Martin HrabMe de Angelis, Daniela Vogt Weisenhorn, Wolfgang Wurst and Sabine M. H？lter. Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors. (*Co-first author) Frontiers in Behavioral Neuroscience. 2015，9:302.
26. Marina Theodorou*, Benedict Rauser*, Jingzhong Zhang*, Nilima Prakash, Wolfgang Wurst, Joel A. Schick. Limitations of in vivo reprogramming to dopaminergic neurons via a tricistronic strategy. (*Co-first author) Human gene therapy Methods. 2015, 26(4):107-22.
27. Jingzhong Zhang, Sebastian G？tz, Daniela M. Vogt Weisenhorn, Antonio Simeone, Wolfgang Wurst and Nilima Prakash. A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/– mice. Neurobiology of Disease. 2015,82: 32-45.
张京钟 研究员
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