研究员,细胞工程研究中心负责人,中国科学技术大学博士生导师,国家重点研发计划首席。2005年获得神经生物学博士学位,在Helmholtz慕尼黑中心、德国MDC分子医学中心从事神经发育和干细胞重编程机制研究十余年。在重大疾病的干细胞治疗和基因治疗研究中取得了较多成果,获得江苏省高层次创新创业人才、姑苏重大创新团队领军人才、北京市科技新星、北京市科技进步二等奖等荣誉称号和奖项。发表论文50余篇,申请专利10余项,授权发明专利5项。
1.中国神经科学学会神经干细胞和组织工程分会,常务委员。
2.中国生物工程学会干细胞与组织工程专委会,常务委员。
(1)干细胞/类脑器官治疗神经系统重大疾病及其机制研究;(2)类器官和微生理系统构建及应用。
1. 国家重点研发计划“干细胞研究与器官修复”专项(首席)。
2. 国家自然基金面上项目(项目负责人)。
3. 姑苏重大创新团队项目:干细胞关键技术研发及其核心装备产业化开发(领军人才)。
4. 中国科学院战略先导计划(项目骨干)。
5. 江苏省基础研究重点项目(项目骨干)。
1. Du F, Zhang S, Li S, Zhou S, Zeng D, Zhang J*, Yu S*. Controlled release of mesenchymal stem cell-derived nanovesicles through glucose- and reactive oxygen species-responsive hydrogels accelerates diabetic wound healing. Journal of Controlled Release, 2024 Dec:376:985-998. (Corresponding author )
2. Deng, Q.; Pan, S.; Du, F.; Sang, H.; Cai, Z.; Xu, X.; Wei, Q.; Yu, S.; Zhang, J*.; Li, C*. The Effect of Conditioned Medium from Angiopoietin-1 Gene-Modified Mesenchymal Stem Cells on Wound Healing in a Diabetic Mouse Model. Bioengineering, 2024, 11, 1244. https://doi.org/10.3390/bioengineering11121244. (Co-Corresponding author )
3. Liu H, Wang Y, Zhang X, Zhang M, Wang P, Shang J, Li Z, Gong L, Guo J, Sun W, Pi J, Li X, Ding W, Wang D, Li Z, Zhang J, Wang L, Geng X, Yang R, Zhou P, Tang W, Zhang X, Chen C, Yang S, Qin J. Standard: human intestine-on-a-chip. Cell Regen. 2024 Aug 5;13(1):16. doi: 10.1186/s13619-024-00198-7.
4. Tao Q, Yang S, Wang S, Yang Y, Yu S, Pan Y, Li Y, Zhang J*, Hu C*. Neural Progenitor Cell-Mediated Magnetic Nanoparticles for Magnetic Resonance Imaging and Photothermal Therapy of Glioma. ACS Appl Bio Mater. 2024 Jul 15;7(7):4553-4561. doi: 10.1021/acsabm.4c00414. (Co-Corresponding author )
5. Peng H, Du F, Wang J, Wu Y, Wei Q, Chen A, Duan Y, Shi S, Zhang J, Yu S. Adipose-Derived Stem-Cell-Membrane-Coated PLGA-PEI Nanoparticles Promote Wound Healing via Efficient Delivery of miR-21. Pharmaceutics. 2024 Aug 23;16(9):1113. (Corresponding author )
6. Wei Q, Liu M, Li S, Shi S, Du F, Peng H, Zeng D, Deng Q, Pan S, Zhang J*, Yu S*. The composite biomatrix SC/CM improved the therapeutic effects of xenogeneic MSC on wound healing in immune-competent mice via immune niche reprogramming. J. Mater Sci., 2024,59, 15514–15528. (Corresponding author )
7. Zhang Z, Wang R, Zhou H, Wu D, Cao Y, Zhang C, Sun H, Mu C, Hao Z, Ren H, Wang N, Yu S, Zhang J, Tao M, Wang C, Liu Y, Liu L, Liu Y, Zang J, Wang G. Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model. Cell Mol Life Sci. 2024 Mar 12;81(1):128. doi: 10.1007/s00018-024-05176-5.
8. Liu Y, Ge Y, Wu Y, Feng Y, Liu H, Cao W, Xie J, Zhang J*. High-Voltage Electrostatic Field Hydrogel Microsphere 3D Culture System Improves Viability and Liver-like Properties of HepG2 Cells. Int J Mol Sci. 2024 Jan 16;25(2):1081. doi: 10.3390/ijms25021081. (Corresponding author )
9. Wang L, Liu S, Li K, Ma A, Hu C, Wang C, Cao N, Zhao Y, Fu R, Jia W, Xiang P, Liu H, Qi Z, Zhu N, Liang L, Wang L, Cao J, Zhai P, Zhou J, Wei J, Na T, Wu J, He Z, Zhou G, Yu W, Wu J, Zeng W, Zhang Y, Zhu L, Fu B, Zhang J, Yang S, Dai C, Cui H, Jing J, Yan H, He X, Lu Y, Tong C, Zhao T, Hao J, Liu X, Jin Y, Wang Y. General requirements for the production of extracellular vesicles derived from human stem cells. Cell Prolif. 2024 Mar;57(3):e13554.
10. Ji X, Zhou S, Wang N, Wang J, Wu Y, Duan Y, Ni P, Zhang J*, Yu S*. Cerebral-Organoid-Derived Exosomes Alleviate Oxidative Stress and Promote LMX1A-Dependent Dopaminergic Differentiation. Int J Mol Sci. 2023 Jul 4;24(13):11048. doi: 10.3390/ijms241311048. (Corresponding author )
11. Fangzhou Du, Mengmeng Liu, Jingwen Wang , Lvzhong Hu , Dongao Zeng,Shaocong Zhou, Lixing Zhang , Meijia Wang , Xi Xu , Chenglong Li*, Jingzhong Zhang*, Shuang Yu*. Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation. Metabolism--Clinical and Experimental, 2023 Mar; 140:155398. (Corresponding author )
12. Mao J, Li J, Chen J, Wen Q, Cao M, Zhang F, Li B, Zhang Q, Wang Z, Zhang J, Shen J. CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma. J Immunother Cancer. 2023 Dec 6;11(12):e007481.
13. Menon R, Petrucci L, Lohrer B, Zhang J, Schulze M, Schichor C, Winner B, Winkler J, Riemenschneider MJ, Kühn R, Falk S, Karow M.Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons. Cell Reprogram. 2023 Jun 27. doi: 10.1089/cell.2023.0008.
14. Lvzhong Hu, Jinhua Zhou, Zhisong He, Lin Zhang, Fangzhou Du, Mengting Nie, Yao Zhou, Hang Hao, Lixing Zhang, Shuang Yu*, Jinzhong Zhang*, Youguo Chen*. In situ-formed fibrin hydrogel scaffold loaded with human umbilical cord mesenchymal stem cells promotes skin wound healing. Cell Transplantation. 2023; 32:9636897231156215. (Co-corresponding author )
15. Lixing Zhang, Xin Miao, Meijia Wang, Aihua Shi, Jingwen Wang, Zhonglin Ma, Yunhai Zhang, Jingzhong Zhang*, Shuang Yu*. Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing. Bio design and manufacturing, 2023;6:268–283. ( Corresponding author )
16. Y. C. Zhang, J. W. Wang, Y. Wu, Q. Tao, F. F. Wang, N. Wang, X. R. Ji, Y. G. Li, S. Yu*, J. Z. Zhang*. Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain. Molecular Biology, 2022;56(3):500-502. (Corresponding author )
17. Nana Wang, Xingrui Ji, Yue Wu, Shaocong Zhou, Huiyu Peng, Jingwen Wang, Shuang Yu*,and Jingzhong Zhang*. The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells. Int J Mol Sci. 2021; 22(22): 12141(Corresponding author )
18. Zhang L, Yan X, An L, Wang M, Xu X, Ma Z, Nie M, Du F, Zhang J*, Yu S*. Novel pneumatically assisted atomization device for living cell delivery and application of sprayed mesenchymal stem cells in skin regeneration. Bio design and manufacturing, 2022; 5, 220–232. (Corresponding author )
19. Wang S, Shen H, Mao Q, Tao Q, Yuan G, Zeng L, Chen Z, Zhang Y, Cheng L, Zhang J, Dai H, Hu C, Pan Y, Li Y. Macrophage-Mediated Porous Magnetic Nanoparticles for Multimodal Imaging and Postoperative Photothermal Therapy of Gliomas. ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56825-56837.
20. Yao Zhou, Jinhua Zhou, Xi Xu, Fangzhou Du, Mengting Nie, Lvzhong Hu, Yuhao Ma, Mengmeng Liu, Shuang Yu*, Jingzhong Zhang*, Youguo Chen*. Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. 2021; 30(15):782-796. (Co-corresponding author )
21. An L, Tao Q, Wu Y, Wang N, Liu Y, Wang F, Zhang L, Shi A, Zhou X, Yu S*, Zhang J*. Synthesis of SPIO nanoparticles and the subsequent applications in stem cell labeling for Parkinson's disease. Nanoscale Res Lett, 2021, 16:107. (Corresponding author )
22. Jana Heppt, Marie-Theres Wittmann, Jingzhong Zhang, Daniela Vogt-Weisenhorn, Nilima Prakash, Wolfgang Wurst, Makoto Mark Taketo, D. Chichung Lie. β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. EMBO Journal, 2020 Nov 2; 39(21): e104472.
23. Yan Liu, Yehui Zhou, Kuo-Hsiang Huang, Xujie Fang, Ying Li, Feifei Wang, Li An, Qingfei Chen, Yunchao Zhang, Aihua Shi, Shuang Yu*, and Jingzhong Zhang*. Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor. CELL PROLIFERATION, 2020;00:e12858 (Corresponding author )
24. Qingfei Chen, Feifei Wang, Yunchao Zhang, Yan Liu, Li An, Zhongliang Ma, Jingzhong Zhang*, Shuang Yu*. Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction BDNF expression in developmental stages. Biochemical and Biophysical Research Communications, 2020, Vol.527(1): 311-316 (Corresponding author )
25. Yang Z, Zheng C, Zhang F, Lin B, Cao M, Tian X, Zhang J, Zhang X, Shen J. Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis. Muscle Nerve. 2020 Mar 14. doi: 10.1002/mus.26862.
26. Mao J, Cao M, Zhang F, Zhang J, Duan X, Lu L, Yang Z, Zhang X, Zhu W, Zhang Q, Wang Z, Shen J. Peritumoral administration of IFNβ upregulated mesenchymal stem cells inhibits tumor growth in an orthotopic, immunocompetent rat glioma model. J Immunother Cancer. 2020 Mar;8(1). pii: e000164. doi: 10.1136/jitc-2019-000164.
27. Liu Y, Song H, Yu S, Huang K-H, Ma X, Zhou Y, Zhang J*, Chen L*. Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c‐MYC axis in breast cancer. J Cell Mol Med.,2020;24:2135–2144. (Co-corresponding author )
28. Liu Y, Zhou Y, Huang KH, Li Y, Fang X, An L, Wang F, Chen Q, Zhang Y, Shi A, Yu S*, Zhang J*. EGFR-specific CAR-T cells trigger cell lysis in EGFR-positive TNBC. Aging (Albany NY). 2019 Dec 4;11(23):11054-11072. (Corresponding author )
29. Yu N, Zhang X, Gao Y, You H, Zhang J*, Miao P*. Highly Sensitive Endotoxin Assay Combining Peptide/Graphene Oxide and DNA-Modified Gold Nanoparticles. ACS Omega. 2019, 22; 4(10): 14312-14316. (Co-corresponding author )
张京钟 研究员
研究方向:
电子邮件:zhangjz@sibet.ac.cn
电 话:0512-69588288
通讯地址: