从事制药和生物技术领域的研究与开发的工作十余年。2014年回国任中国科学院“百人计划”特聘研究员，博士生导师，中国科学院苏州生物医学工程技术研究所核酸检测技术研究中心副主任。北京大学生物学学士学位，美国约翰霍普金斯大学医学院分子生物学博士和博士后。回国前先后担任美国默沙东制药公司（MSD, Merck & Co., Inc.）高级生物学家，Quintara Biosciences科学家和BioChain Institute, Inc.科学家兼项目负责人。在癌症相关的信号传导途径、RNA干扰、功能性基因组学、细胞检测方法开发、活体和体外药物靶标的鉴定和验证等方面具有丰富的理论与研发经验。在国际顶级科研杂志（《细胞》、《自然》等）发表多篇论文，并在美国专利和商标局申请有多项专利。回国以来，在研或验收包括国家重点专项、省专项等科研人才类项目十余项，发表科研论文和专利三十多篇（项）。国家高端外国专家、江苏省免疫学会委员、江苏省“引智计划”、苏州市“海鸥计划”、苏州市“高等院校、科研院所紧缺高层次人才”、苏州市优秀人才等。
1、 国家高端外国专家（2021）
2、 江苏省“引智计划”（2020）
3、 苏州市“海鸥计划”（2020）
4、 苏州市优秀人才贡献奖（2018）
5、 苏州市高等院校、科研院所紧缺高层次人才（2017）
6、 中国科学院“百人计划”（2014）
7、 开发了两个癌症早期筛查与诊断的体外分子诊断试剂盒
8、 用活体RNA干扰技术验证了3个癌症药物靶标
9、 向美国专利与商标局申请了3个用RNA干扰技术抑制基因表达的发明专利，其中1个已授权
10、 作为第一作者在英国《自然》杂志（Nature）发表了一篇具有里程碑意义的科研论文，且这篇论文引发了在不同杂志上发表的多篇评论文章
11、 作为第一作者在美国《细胞》杂志（Cell）发表了一篇科研论文
12、 作为共同作者在美国《细胞》杂志（Cell）发表了两篇科研论文
13、 入选美国最悠久的学术荣誉协会- 协会（2003）
14、 博士学位候选人口试表现出色的特别表彰（1997）
1、 体外分子诊断方法和应用
2、 癌症早期筛查和诊断
3、 核酸杂交与结构
1. Qianqian Wang, Daniel E.Asarnow, Ke Ding, Randall K. Mann, Janson Hatakeyama, Yunxiao Zhang, Yong Ma, Yifan Cheng*, Philip A.Beachy*, Dispatched uses Na+ flux to power release of lipid-modified Hedgehog, Nature, 2022.（SCI）
2. Yang Cao, Guodong Zhao, Yaping Tian, Zhiliang Chen, Xiaoyu Liu, Mufa Yuan, Jun Yang, Xiaomei Wang, Yong Ma, Zhaocheng Liu, Shangmin Xiong*, Minxue Zheng*, Sujuan Fei*, Feasibility of methylated CLIP4 in stool for early detection of colorectal cancer: a training study in Chinese population, Frontiers in Oncology, 2021.（SCI）
3. Guoying Zhang, Fang He, Guodong Zhao, Zizhui Huang, Xiang Li, Xia Xia, Yidi Guo, Weiping Xu, Shangmin Xiong, Yong Ma, Minxue Zheng*, Wanli Liu*, Combining serum DNA methylation biomarkers and protein tumor markers improved clinical sensitivity for early detection of colorectal cancer, International Journal of Genomics, 2021.（SCI）
4. Zhaocheng Liu, Chengxue Zhao, Guodong Zhao, Shangmin Xiong*, Yong Ma*, Minxue Zheng*, Disruptors, a new class of oligonucleotide reagents, significantly improved PCR performance on templates containing stable intramolecular secondary structures, Analytical Biochemistry, 2021.（SCI）
5. Guodong Zhao, Xiaoyu Liu, Yi Liu, Yong Ma, Jun Yang, Hui Li, Shangmin Xiong, Sujuan Fei,* Minxue Zheng*, Xiangwei Zhao*, Methylated SFRP2 and SDC2 in Stool Specimens for Colorectal Cancer Early Detection: A Cost-effective Strategy for Chinese Population, Journal of Cancer, 2021.（SCI）
6. Yaping Cao, Guodong Zhao, Mufa Yuan, Xiaoyu Liu, Yong Ma, Yang Cao, Bei Miao, Shuyan Zhao, Danning Li, Shangmin Xiong*, Minxue Zheng*, Sujuan Fei*, KCNQ5 and C9orf50 methylation in stool DNA for early detection of colorectal cancer, Frontiers in Oncology, 2021.（SCI）
7. Guodong Zhao, Zhengzheng Wang, Shangmin Xiong, Xiaoyu Liu, Yun Zhu, Shiming Li, Yong Ma*, Minxue Zheng*, Feasibility of Multiplex Methylated DNA Testing in Serum for Detection of Upper Gastrointestinal Tract Cancers, Test Engineering and Management, 2020.（SCI）
8. Guodong Zhao, Xiaoyu Liu, Yi Liu, Hui Li, Yong Ma, Shiming Li, Yun Zhu, Jin Miao, Shangmin Xiong*, Sujuan Fei*, Minxue Zheng*, Aberrant DNA Methylation of SEPT9 and SDC2 in Stool Specimens as an Integrated Biomarker for Colorectal Cancer Early Detection, Front Genet, 2020.（SCI）
9. Guodong Zhao, Yong Ma, Hui Li, Shiming Li, Yun Zhu, Xiaoyu Liu, Shangmin Xiong, Yi Liu, Jin Miao, Sujuan Fei*, Minxue Zheng*, Xiangwei Zhao*, A novel plasma based early colorectal cancer screening assay based on methylated SDC2 and SFRP2, Clinica Chimica Acta, 2020.（SCI）
10. Jin Miao？, Yi Liu？, Guodong Zhao, Xiaoyu. Liu, Yong Ma, Hui Li, Shiming Li, Yun Zhu, Shangmin Xiong*, Minxue Zheng*, Sujuan Fei*, Feasibility of plasma methylated SFRP2 for early detection of gastric cancer, Cancer Control, 2020.（SCI）
11. Guodong Zhao, Yi Liu, Jin Miao, Hui Li , Yong Ma, Xiaoyu Liu, Shiming Li, Yun Zhu, Shangmin Xiong*, Minxue Zheng*, Sujuan Fei*, Performance comparison between plasma and stool methylated SEPT9 tests for detecting colorectal cancer, Frontiers in Genetics, 2020.（SCI）
12. Zhaocheng Liu, Jinli Sun, Guodong Zhao, Shangmin Xiong*, Yong Ma*, Minxue Zheng*, Transient stem-loop structure of nucleic acid template may interfere with__polymerase chain reaction through endonuclease activity of Taq DNA__polymerase, Gene, 2020.（SCI）
13. Guodong Zhao, Hui Li, Zixuan Yang, Zhenzhen Wang, Shangmin Xiong, Shiming Li, XiaoTing Wu, Xiaoyu Liu, Ziwen Wang, Yun Zhu, Yong Ma*, Sujuan Fei*, Minxue Zheng*, Multiplex Methylated DNA Testing in Plasma with High Sensitivity and Specificity for Colorectal Cancer Screening, Cancer Medicine, 2020.（SCI）
14. Jinli Sun, Yaping Tian, Yingying Du, Zhenzhen Wang, Guodong Zhao*, Yong Ma*, Minxue Zheng*, A Cautionary Tale of Cross Contamination among Plasmids from Commercial Suppliers, Biotechniques, 2020.（SCI）
15. Jinli Sun, Yang Shi, Guodong Zhao*, Yingying Du, Zhenzhen Wang, Zhaocheng Liu, Hui Wang, Yong Ma*, Minxue Zheng*, Rapid detection of diarrheagenic Escherichia coli in food by a new multiplex real-time Quantitative PCR Assay, Applied Biochemistry and Microbiology, 2020.（SCI）
16. Yingying Du, Guodong Zhao, Zhaocheng Liu, Jinli Sun, Minxue Zheng*, Yong Ma*, Comparison of CerviHPV and cobas 4800 HPV Tests for Detection of High-risk HPV Infection in Cervical Swab Specimens, Journal of Reproductive Medicine, 2020.（SCI）
17. Hui Li, Zhenzhen Wang, Guodong Zhao, Yong Ma, Ying Chen, Qi Xue, Minxue Zheng*, Sujuan Fei*, Performance of a MethyLight assay for methylated SFRP2 DNA detection in colorectal cancer tissue and serum, The International Journal of Biological Markers, 2019. SCI）
18. Ying Chen, Zhenzhen Wang, Guodong Zhao, Chuang Sun, Yong Ma, Linyan Zhang, Minxue Zheng*, Hngchun Li*, Performance of a Novel Blood based Early Colorectal Cancer Screening Assay in Remaining Serum after Blood Biochemical Test, Clinical Chemistry and Laboratory Medicine, 2019.（SCI）
19. Guodong Zhao, Yaping Tian, Yingying Du, Jinli Sun, Zhenzhen Wang, Yong Ma*, Minxue Zheng*, Comparison of CerviHPV and Hybrid Capture 2 HPV Tests for Detection of High-risk HPV Infection in Cervical Swab Specimens, Diagnostic Cytopathology, 2018.（SCI）
20. Guodong Zhao, Zhaocheng Liu, Yaping Tian, Minsheng Zhu, Shouli Wang, Hui Wang, Shen Gao, Yong Ma* and Minxue Zheng*, Stability, Integrity and Recovery Rate of Cellular Nucleic Acids Preserved in a New Liquid-Based Cytology Medium, Diagnostic Cytopathology, 2018.（SCI）
21. Yong Ma, Adrian Creanga, Lawrence Lum, Philip A. Beachy*, Prevalence of Off-Target Effects in Drosophila RNA Interference Screens, Nature, 2006.（SCI）
22. Yong Ma, Alfrun Erkner, Ruoyu Gong, Shenqin Yao, Jussi Taipale, Konrad Basler, Philip A. Beachy*, Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched, Cell, 2002.（SCI）
23. Chien-Huan Chen, Doris P. Von Kessler, Woojin Park, Baolin Wang, Yong Ma, Philip A. Beachy*, Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression, Cell, 1999.（SCI）
24. Jeffery A. Porter, Stephen C. Ekker, Woo-Jin Park, Doris P. von Kessler, Keith E. Yong, Chien-Huan Chen, Yong Ma, Amina S. Woods, Robert J. Cotter, Eugene V. Koonin, Philip A. Beachy*, Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain, Cell, 1996.（SCI）
知识产权：
1. 郑岷雪，马勇，赵国栋，刘派，李甲，宫颈细胞保存及DNA快速提取一体试剂盒和提取方法，发明专利，ZL201510896289.4
2. 郑岷雪，马勇，赵国栋，高信噪比多探针PCR Taqman探针及其应用，发明专利，ZL 201710184261.7
3. 郑岷雪，马勇，赵国栋，对多种高危型人乳头瘤病毒实现分型的试剂盒，发明专利，ZL201711367631.7
4. 刘兆成，马勇，郑岷雪，赵国栋，熊尚岷，用于提高具有二级结构的单链核酸分子的复制效率的试剂、核酸片段复制方法、应用，PCT国际专利，PCT/CN2021/131637
5. 顾兵，陈莹，赵呈雪，张林艳，马勇，郑岷雪，在单管qPCR中同时检测多种肠道致病菌的组合物、试剂盒及方法，发明专利，202111168379.3
6. 陈莹，顾兵，赵呈雪，张林艳，马勇，郑岷雪，使用多重qPCR快速检测并鉴定多种肠道致病菌的组合物、试剂盒及方法，发明专利，202111168378.9
7. 刘兆成，马勇，郑岷雪，赵国栋，熊尚岷，用于提高具有二级结构的单链核酸分子的复制效率的试剂、核酸片段复制方法、应用，发明专利，202011442674.9
8. 刘兆成，马勇，郑岷雪，赵国栋，熊尚岷，张春，用于提高腺相关病毒反向末端重复序列的复制效率的试剂 、腺相关 病毒DNA的复制方法、应用，发明专利，202011442675.3
9. 杜莹莹，古洁若，马勇，郑岷雪，痛风差异表达基因检测与急性发作预警试剂盒，发明专利，201810978764.6
10. 郑岷雪，马勇，赵国栋，对多种高危型人乳头瘤病毒实现分型的试剂盒，发明专利，ZL201711367631.7
11. S. Bartz, D. Brown, Y. Ma, RNA Interference Mediated Inhibition of Isocitrate Dehydrogenase (IDH1) Gene Expression Using Short Interfering Nucleic Acid (siNA), 美国专利，US 9,322,020 B2
12. S. Bartz, D. Brown, Y. Ma, J. Semyonov, RNA Interference Mediated Inhibition of Mitogen-activated Protein Kinase 1 (MAPK1) Gene Expression Using Short Interfering Nucleic Acid (siNA). Pending patent application with US Patent and Trademark Office, 国际专利， WO2012021383 A3
13. S. Bartz, D. Brown, E. A. Harrington, Y. Ma, U. Philippar, RNA Interference Mediated Inhibition of MET Gene Expression Using Short Interfering Nucleic Acid (siNA). Pending patent application with US Patent and Trademark Office, 国际专利，WO2011130065 A1
马勇 研究员
研究方向：
电子邮件：mayong@sibet.ac.cn
电 话：0512-69588328
通讯地址：苏州高新区科灵路88号