高山  研究员  

研究方向:

电子邮件:

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获奖及荣誉:

 

社会任职:

 

研究方向:

  •  肿瘤分子基础和生物标志物;
  •  药物机理和生物标志物
  •  肿瘤免疫治疗技术和分子机理

承担项目情况:

 

代表论著:

1.     Yang XW, Wen Y, Liu SM, Duan LQ, Liu QF, Tong Z, Wang Z, Gu YM, Xi YB, Wang XD, Luo DS, Zhang RB, Liu YJ, Wang Y, Cheng TY, Jiang SY, Zhu XF, Yang XH, Pan YB, Cheng SW, Ye QN, Chen JF*, Xu XD*, Gao S*. LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival. Proc Natl Acad Sci U S A 2021, In Press

2. Gu YM, Niu SX, Wang Y, Duan LQ, Pan YB, Tong Z, Zhang X, Yang Z, Peng B, Wang XD, Han XQ, Li YJ, Cheng TY, Liu Y, Shang LN, Liu T, Yang X, Sun S, Jiang SY, Zhang C, Zhang N, Ye QN, Gao S*. DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression. Cancer Res 2021, 81:923-34

3. Wang XD, Yang XH, Zhang C, Wang Y, Cheng TQ, Tong Z, Tan SG, Zhang H, Saw PE, Gu YM, Wang J, Zhang Y, Shang L, Liu Y, Jiang S, Yan B, Li R, Yang Y, Yu J, Chen Y, Gao GF*, Ye QN, Gao S*. Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy. Proc Natl Acad Sci U S A 2020, 117(12): 6640-6650.

4. Jiang SY, Wang XT, Song D, Liu X, Gu Y, Xu Z, Wang X, Zhang X, Ye QN, Tong Z, Yan B, Yu J, Chen Y, Sun M, Wang Y, Gao S*. Cholesterol Induces Epithelial-to-Mesenchymal Transition of Prostate Cancer Cells by Suppressing Degradation of EGFR through APMAP. Cancer Res 2019, 79(12): 3063-3075.

5. Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, Yang X, Teng Y, Lin J, Huang J, Jin R, Wu J, Liu B, Chang S, Wang E, Zhang C, Hou N, Cheng X, Xu D, Yang X*, Gao S*, Ye QN*. PES1 is a critical component of telomerase assembly and regulates cellular senescence. Sci Adv 2019, 5(5): eaav1090.