报告人：王珲 

　　主持人：董文飞 

　　报告时间：2015年03月10日（星期二）下午3：00 

　　报告地点：A3行政综合楼516会议室 

　　报告摘要： 

　　Next generation sequencing for virus discovery and beyond 

　　Hui WANG 

　　Department of Zoology, University of Oxford, Oxford OX1 3PS, UK 

　　NERC/Centre for Ecology & Hydrology, Wallingford, Oxfordshire OX10 8BB, UK 

　　There are approximately 5000 viral (species) reference genomes available in the public database whereas an estimate of the total viral species in the planet is in the range of 100 million including approximately 300,000 unknown species infecting mammals. Such a huge knowledge gap makes our strategies against viral diseases passive and in many cases, inefficient. The next generation sequencing (NGS) technology now offers a new capacity to make significant progress. The metagenomics approach has been proven to be powerful for disease aetiology and pathogen discovery. However, information gathering practice for viruses has not been routinely applied in genomics studies. In many research projects, sequence reads are firstly mapped against the reference genome(s) of interested (host) species and unmapped reads were no longer included in further analyses. Because NGS unselectively produces sequences of both hosts and the viruses infecting them, the NGS datasets are valuable resources for virus identification and discovery. In addition to a consensus sequence that conventional sequencing produces, a NGS dataset often enables further investigation on polymorphisms of viral genome positions. As NGS can easily achieve a deep coverage of a virus genome, NGS datasets offer new opportunities to investigate viral population structure and dynamics. It has been well demonstrated that many viruses have large populations with quasi-species characteristics. The structure and dynamics of viral quasi-species is an important factor for assessing viral threats of emerging diseases as well as for developing efficient strategies of anti-viral treatments. Due to the wide range of viral infections, exploitation of the new NGS opportunities will benefit not only the basic research of virology but also a much wider research community and beyond.     

　　报告人简历：Research areas: 

　　Applications of next generation sequencing (NGS), molecular biology, virology, molecular parasitology, immunology, vector biology, pathogen-vector-host interactions, molecular ecology and evolution, live cell based biosensor. 

　　Positions:  

　　2014-present  Senior Research Fellow on Genomics, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK  

　　2002-2014       Principal Scientific Officer (NERC Band 4) and Group Leader of Plant Virus, NERC/CEH-Oxford, then NERC/CEH-Wallingford since 2010, OX10 8BB, UK 

　　1999-2001       Senior Scientific Officer (NERC Band 5), NERC/CEH-Oxford, Oxford OX1 3SR, UK 

　　1995-1999       Postdoctoral Higher Scientific Officer (NERC Band 6), NERC/Institute of Virology and Environmental Microbiology (IVEM), Oxford OX1 3SR, UK 

　　1991-1995       Research Student for D. Phil., Dept Biochemistry, University of Oxford, UK 

　　1990-1991       Research Assistant, Institute of Genetics, Chinese Academy of Science, Beijing, China 

　　Degrees: 

　　March 1995     D.Phil, Virology, St Cross College/Department of Biochemistry, University of Oxford, Oxford, UK.  

　　June 1990        M.Sc, Plant Physiology, College of Biological Sciences, Beijing Agricultural University, Beijing, China. 

　　July 1987        B.Sc, Agriculture, Department of Agronomy, Beijing Agricultural University, Beijing, China. 

　　Honour and professional service: 

　　2014-present   Research Fellow, NERC/CEH, Wallingford OX10 8BB, UK 

　　2013-16   Distinguished Visiting Professor, Shenzhen Key Research Discipline of Emerging Infectious Diseases, Shenzhen 3rd People’s Hospital, Shenzhen, China 

　　2012-16    Visiting Professor, College of Veterinary Medicine, China Agricultural University, Beijing, China 

　　2010-12    Visiting Professor, Beijing Genomics Institute (BGI)-Shenzhen, China 

　　2009-11    Honorary Professor, State Key Laboratory for Biology of Plant Diseases and Insect Pests, Chinese Academy of Agricultural Sciences 

　　2009-12    Adjunct Professor, College of Environmental Sciences, Nankai University, Tianjin, China  

　　2004- Association of Applied Biologist (member) 

　　1996- Common Room, Wolfson College, University of Oxford (member)  

　　欢迎大家踊跃参加！ 

                                                2015年3月05日

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